Persistent Hypersomnolence Following Clobazam in a Child With Epilepsy and Undiagnosed CYP2C19 Polymorphism
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چکیده
منابع مشابه
Clobazam and Its Use in Epilepsy
Clobazam (CLB) is an older anti-epileptic drug, with a slightly different chemical structure from that of the classic benzodiazepines currently used in the treatment of epilepsy, which confers less sedative properties in terms of negative adverse effects. It is also thought to be better tolerated than other anti-epileptic drugs, whilst maintaining a very similar level of efficacy. It has been t...
متن کاملGenetic Polymorphism of CYP2C19 in Pakistani Population
CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...
متن کاملGenetic Polymorphism of CYP2C19 in Pakistani Population
CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...
متن کاملClobazam as adjunctive treatment in refractory epilepsy.
IF~ ~~' Pyelograms from two identical twins. (a) Case 1, showing left chronic pyelonephritis; renal outlines have been pencilled in for clarity. (b) Case 2, showing normal appearances apart from a minor degree of duplex bilaterally. Case reports Case 1-This patient was investigated at the age of 18 for recurrent urinary infection. She had been aware of symptoms only for the preceding few months...
متن کاملHypothermia associated with clobazam use in adult epilepsy
Clobazam, a 1,5-benzodiazepine FDA-approved in 2011, is commonly used to treat anxiety and epilepsy. It has not associated with hypothermia until very recently, in a case report involving two pediatric patients. Here, we report the first case of hypothermia development in an adult patient with epilepsy associated with clobazam use. A couple months after starting clobazam, the patient started de...
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ژورنال
عنوان ژورنال: The Journal of Pediatric Pharmacology and Therapeutics
سال: 2020
ISSN: 1551-6776
DOI: 10.5863/1551-6776-25.4.320